Dr. Manuel Ruiz-Aravena

Falvo, C. A., Crowley, D. E., Benson, E., Hall, M. N., Schwarz, B., Bohrnsen, E., Ruiz Aravena, M., Hebner, M., Ma, W., Schountz, T., others, . 2025. Diet-induced changes in metabolism influence immune response and viral shedding in Jamaican fruit bats. Proceedings B of the Royal Society 292(2041):20242482.

Bell, O., Jones, M. E., Ruiz Aravena, M., Hamilton, D. G., Comte, S., Hamer, R., Hamede, R. K., Newton, J., Bearhop, S., McDonald, R. A. 2024. Human habitat modification, not apex scavenger decline, drives isotopic niche variation in a carnivore community. Oecologia 204(4):943--957.

Borremans, B., Falvo, C. A., Crowley, D. E., Hoegh, A., Lloyd-Smith, J. O., Peel, A. J., Restif, O., Ruiz Aravena, M., Plowright, R. K. 2024. Reconstructing prevalence dynamics of wildlife pathogens from pooled and individual samples. Peer Community Journal 4.

Crowley, D. E., Falvo, C. A., Benson, E., Hedges, J., Jutila, M., Ezzatpour, S., Aguilar, H. C., Ruiz Aravena, M., Ma, W., Schountz, T., Ryanda-Apple, A., Plowright, R. K. 2024. Bats generate lower affinity but higher diversity antibody responses than those of mice, but pathogen-binding capacity increases if protein is restricted in their diet. PLoS Biology 22(9):e3002800.

Plowright, R. K., Ahmed, A. N., Coulson, T., Crowther, T. W., Ejotre, I., Faust, C. L., Frick, W. F., Hudson, P. J., Kingston, T., Nameer, P. O., O'Mara, M. T., Peel, A. J., Possingham, H., Razgour, O., Reeder, D. M., Ruiz Aravena, M., Simmons, N. B., Srinivas, P. N., Tabor, G. M., Tanshi, I., Thompson, I. G., Vanak, A. T., Vora, N. M., Willison, C. E., Keeley, A. T. 2024. Ecological countermeasures to prevent pathogen spillover and subsequent pandemics. Nature Communications 15(1):2577.

Gallinson, D. G., Kozakiewicz, C. P., Rautsaw, R. M., Beer, M. A., Ruiz Aravena, M., Comte, S., Hamilton, D. G., Kerlin, D. H., McCallum, H. I., Hamede, R., Jones, M. E., Storfer, A., McMinds, R., Margres, M. J. 2024. Intergenomic signatures of coevolution between Tasmanian devils and an infectious cancer. Proceedings of the National Academy of Sciences 121(12).

Raven, N., Klaasen, M., Madsen, T., Jones, M. E., Hamilton, D. G., Ruiz Aravena, M., Thomas, F., Hamede, R. K., Ujvari, B. 2024. Complex associations between cancer progression and immune gene expression reveals early influence of transmissible cancer on Tasmanian devils. Frontiers in Immunology

Corti, P., Collado, B., Salgado, M., Moraga, C. A., Radic-Schilling, S., Tejeda, C., Ruiz Aravena, M. 2022. Dynamic of Mycobacterium avium subspecies paratuberculosis infection in a domestic--wildlife interface: domestic sheep and guanaco as reservoir community. Transboundary and Emerging Diseases 69(4):e161--e174.

Reaser, J. K., Hunt, B. E., Ruiz Aravena, M., Tabor, G. M., Patz, J. A., Becker, D. J., Locke, H., Hudson, P. J., Plowright, R. K. 2022. Fostering landscape immunity to protect human health: A science-based rationale for shifting conservation policy paradigms. Conservation Letters 15(3):e12869.

Estay, S. A., Ruiz-Aravena, M., Baader, T., Gotelli, M., Heskia, C., Olivares, J. C., Rivera, G. 2022. Socioeconomic and environmental contexts of suicidal rates in a latitudinal gradient: Understanding interactions to inform public health interventions. Journal of Psychiatric Research 148(July 2021):45--51.

Corti, P., Collado, B., Salgado, M., Moraga, C. A., Radic‐Schilling, S., Tejeda, C., Ruiz‐Aravena, M. 2022. Dynamic of Mycobacterium avium subspecies paratuberculosis infection in a domestic–wildlife interface: Domestic sheep and guanaco as reservoir community. Transboundary and Emerging Diseases 69(4).

Ruiz Aravena, M., McKee, C., Gamble, A., Lunn, T., Morris, A., Snedden, C. E., Yinda, C. K., Port, J. R., Buchholz, D. W., Yeo, Y. Y., Faust, C., Jax, E., Dee, L., Jones, D. N., Kessler, M. K., Falvo, C., Crowley, D., Bharti, N., Brook, C. E., Aguilar, H. C., Peel, A. J., Restif, O., Schountz, T., Parrish, C. R., Gurley, E. S., Lloyd-Smith, J. O., Hudson, P. J., Munster, V. J., Plowright, R. K. 2022. Ecology, evolution and spillover of coronaviruses from bats. Nature Reviews Microbiology 20(5):299-314.

Reaser, J. K., Hunt, B. E., Ruiz‐Aravena, M., Tabor, G. M., Patz, J. A., Becker, D. J., Locke, H., Hudson, P. J., Plowright, R. K. 2022. Fostering landscape immunity to protect human health: A science‐based rationale for shifting conservation policy paradigms. Conservation Letters 15(3).

Hansen, D., Hunt, B. E., Falvo, C. A., Ruiz-Aravena, M., Kessler, M. K., Hall, J., Thompson, P., Rose, K., Jones, D. N., Lunn, T. J., Dale, A. S., Peel, A. J., Plowright, R. K. 2022. Morphological and quantitative analysis of leukocytes in free-living Australian black flying foxes (Pteropus alecto). PLOS ONE 17(5):e0268549.

Estay, S. A., Ruiz Aravena, M., Baader, T., Gotelli, M., Heskia, C., Olivares, J. C., Rivera, G. 2022. Socioeconomic and environmental contexts of suicidal rates in a latitudinal gradient: Understanding interactions to inform public health interventions. Journal of Psychiatric Research 148:45-51.

Espejo, C., Wilson, R., Pye, R. J., Ratcliffe, J. C., Ruiz Aravena, M., Willms, E., Wolfe, B. W., Hamede, R., Hill, A. F., Jones, M. E., Woods, G. M., Lyons, A. B. 2022. Cathelicidin-3 Associated With Serum Extracellular Vesicles Enables Early Diagnosis of a Transmissible Cancer. Frontiers in Immunology 13.

Espejo, C., Wilson, R., Willms, E., Ruiz Aravena, M., Pye, R. J., Jones, M. E., Hill, A. F., Woods, G. M., Lyons, A. B. 2021. Extracellular vesicle proteomes of two transmissible cancers of Tasmanian devils reveal tenascin-C as a serum-based differential diagnostic biomarker. Cellular and Molecular Life Sciences 78(23):7537-7555.

Kozakiewicz, C. P., Fraik, A. K., Patton, A. H., Ruiz-Aravena, M., Hamilton, D. G., Hamede, R., McCallum, H., Hohenlohe, P. A., Margres, M. J., Jones, M. E., Storfer, A. 2021. Spatial variation in gene expression of Tasmanian devil facial tumors despite minimal host transcriptomic response to infection. BMC Genomics 22(1):698.

Estay, S. A., Ruiz Aravena, M., Baader, T., Gotelli, M., Heskia, C., Olivares, J. C., Rivera, G. 2021. Association of socioeconomic and environmental factors with the spatio-temporal variability of suicide rates along a latitudinal gradient. medRxiv

Hoegh, A., Peel, A., Madden, W., Ruiz Aravena, M., Morris, A., Washburne, A., Plowright, R. 2021. Estimating Viral Prevalence with Data Integration for Adaptive Two-Phase Pooled Sampling.

Kozakiewicz, C. P., Fraik, A. K., Patton, A. H., Ruiz Aravena, M., Hamilton, D. G., Hamede, R., McCallum, H., Hohenlohe, P. A., Margres, M. J., Jones, M. E., others, . 2021. Gene expression of Tasmanian devil facial tumors differs among host populations.

Bell, O., Jones, M. E., Cunningham, C. X., Ruiz Aravena, M., Hamilton, D. G., Comte, S., Hamede, R. K., Bearhop, S., McDonald, R. A. 2021. Isotopic niche variation in Tasmanian devils Sarcophilus harrisii with progression of devil facial tumor disease. Ecology and Evolution 11(12):8038--8053.

Cunningham, C. X., Comte, S., McCallum, H., Hamilton, D. G., Hamede, R., Storfer, A., Hollings, T., Ruiz Aravena, M., Kerlin, D. H., Brook, B. W., others, . 2021. Quantifying 25 years of disease-caused declines in Tasmanian devil populations: host density drives spatial pathogen spread. Ecology Letters 24(5):958--969.

Hoegh, A., Peel, A. J., Madden, W., Ruiz Aravena, M., Morris, A., Washburne, A., Plowright, R. K. 2021. Estimating viral prevalence with data fusion for adaptive two‐phase pooled sampling. Ecology and Evolution 11(20):14012-14023.

Bell, O., Jones, M. E., Cunningham, C. X., Ruiz‐Aravena, M., Hamilton, D. G., Comte, S., Hamede, R. K., Bearhop, S., McDonald, R. A. 2021. Isotopic niche variation in Tasmanian devils Sarcophilus harrisii with progression of devil facial tumor disease. Ecology and Evolution 11(12):8038-8053.

Cunningham, C. X., Comte, S., McCallum, H., Hamilton, D. G., Hamede, R., Storfer, A., Hollings, T., Ruiz‐Aravena, M., Kerlin, D. H., Brook, B. W., Hocking, G., Jones, M. E. 2021. Quantifying 25 years of disease‐caused declines in Tasmanian devil populations: host density drives spatial pathogen spread. Ecology Letters 24(5):958-969.

Reaser, J. K., Tabor, G. M., Becker, D. J., Muruthi, P., Witt, A., Woodley, S. J., Ruiz Aravena, M., Patz, J. A., Hickey, V., Hudson, P. J., Locke, H., Plowright, R. K. 2021. Land use-induced spillover: priority actions for protected and conserved area managers. PARKS

Bell, O., Jones, M. E., Ruiz Aravena, M., Hamede, R. K., Bearhop, S., McDonald, R. A. 2020. Age-related variation in the trophic characteristics of a marsupial carnivore, the Tasmanian devil Sarcophilus harrisii. Ecology and Evolution

Kozakiewicz, C. P., Ricci, L., Patton, A. H., Stahlke, A. R., Hendricks, S. A., Margres, M. J., Ruiz Aravena, M., Hamilton, D. G., Hamede, R., McCallum, H., others, . 2020. Comparative landscape genetics reveals differential effects of environment on host and pathogen genetic structure in Tasmanian devils (Sarcophilus harrisii) and their transmissible tumor. Molecular Ecology

Reaser, J., Hund, B. E., Ruiz Aravena, M., Tabor, G. M., Patz, J. A., Becker, D., Locke, H., Hudson, P., Plowright, R. 2020. Reducing land use-induced spillover risk by fostering landscape immunity: policy priorities for conservation practitioners. EcoEvoRxiv

Patton, A. H., Lawrance, M. F., Margres, M. J., Kozakiewicz, C. P., Hamede, R., Ruiz Aravena, M., Hamilton, D. G., Comte, S., Ricci, L. E., Taylor, R. L., Stadler, T., Leaché, A., McCallum, H., Jones, M. E., Hohenlohe, P. A., Storfer, A. 2020. A transmissible cancer shifts from emergence to endemism in Tasmanian devils. Science 370(6522).

Egan, S. L., Ruiz-Aravena, M., Austen, J. M., Barton, X., Comte, S., Hamilton, D. G., Hamede, R. K., Ryan, U. M., Irwin, P. J., Jones, M. E., Oskam, C. L. 2020. Blood Parasites in Endangered Wildlife-Trypanosomes Discovered During a Survey of Haemoprotozoa from the Tasmanian Devil. Pathogens 9(11):873.

Kozakiewicz, C. P., Ricci, L., Patton, A. H., Stahlke, A. R., Hendricks, S. A., Margres, M. J., Ruiz‐Aravena, M., Hamilton, D. G., Hamede, R., McCallum, H., Jones, M. E., Hohenlohe, P. A., Storfer, A. 2020. Comparative landscape genetics reveals differential effects of environment on host and pathogen genetic structure in Tasmanian devils (Sarcophilus harrisii) and their transmissible tumour. Molecular Ecology 29(17):3217-3233.

Margres, M. J., Ruiz-Aravena, M., Hamede, R., Chawla, K., Patton, A. H., Lawrance, M. F., Fraik, A. K., Stahlke, A. R., Davis, B. W., Ostrander, E. A., Jones, M. E., McCallum, H., Paddison, P. J., Hohenlohe, P. A., Hockenbery, D., Storfer, A. 2020. Spontaneous Tumor Regression in Tasmanian Devils Associated with RASL11A Activation. Genetics 215(4):1143--1152.

Bell, O., Jones, M. E., Ruiz‐Aravena, M., Hamede, R. K., Bearhop, S., McDonald, R. A. 2020. Age‐related variation in the trophic characteristics of a marsupial carnivore, the Tasmanian devil Sarcophilus harrisii. Ecology and Evolution 10(14):7861-7871.

Hamilton, D., Hamede, R., Cameron, E., Ruiz Aravena, M., Comte, S., Jones, M. 2019. Behavioural response to the threat of DFTD in Tasmanian devils. Behaviour, social networks and transmission of devil facial tumour

Peel, A. J., Field, H. E., Aravena, M. R., Edson, D., McCallum, H., Plowright, R. K., Prada, D. 2019. Coronaviruses and Australian bats: a review in the midst of a pandemic. Australian Journal of Zoology 67(6):346.

Patton, A. H., Margres, M. J., Stahlke, A. R., Hendricks, S., Lewallen, K., Hamede, R. K., Ruiz Aravena, M., Ryder, O., McCallum, H. I., Jones, M. E., Hohenlohe, P. A., Storfer, A. 2019. Contemporary Demographic Reconstruction Methods Are Robust to Genome Assembly Quality: A Case Study in Tasmanian Devils. Molecular Biology and Evolution 36(12):2906-2921.

Martin, L. B., Addison, B., Bean, A. G., Buchanan, K. L., Crino, O. L., Eastwood, J. R., Flies, A. S., Hamede, R., Hill, G. E., Klaassen, M., Koch, R. E., Martens, J. M., Napolitano, C., Narayan, E. J., Peacock, L., Peel, A. J., Peters, A., Raven, N., Risely, A., Roast, M. J., Rollins, L. A., Ruiz-Aravena, M., Selechnik, D., Stokes, H. S., Ujvari, B., Grogan, L. F. 2019. Extreme Competence: Keystone Hosts of Infections. Trends in Ecology & Evolution 34(4):303--314.

Bacigalupe, L. D., Gaitán‐Espitia, J. D., Barria, A. M., Gonzalez‐Mendez, A., Ruiz‐Aravena, M., Trinder, M., Sinervo, B. 2018. Natural selection on plasticity of thermal traits in a highly seasonal environment. Evolutionary Applications 11(10):2004-2013.

Ruiz-Aravena, M., Jones, M. E., Carver, S., Estay, S., Espejo, C., Storfer, A., Hamede, R. K. 2018. Sex bias in ability to cope with cancer: Tasmanian devils and facial tumour disease. Proceedings of the Royal Society B: Biological Sciences 285(1891):20182239.

Margres, M. J., Ruiz-Aravena, M., Hamede, R., Jones, M. E., Lawrance, M. F., Hendricks, S. A., Patton, A., Davis, B. W., Ostrander, E. A., McCallum, H., Hohenlohe, P. A., Storfer, A. 2018. The genomic basis of tumor regression in Tasmanian devils (Sarcophilus harrisii). Genome Biology and Evolution 215(4):1143--1152.

Ruiz‐Aravena, M., Gonzalez‐Mendez, A., Estay, S. A., Gaitán‐Espitia, J. D., Barria‐Oyarzo, I., Bartheld, J. L., Bacigalupe, L. D. 2014. Impact of global warming at the range margins: phenotypic plasticity and behavioral thermoregulation will buffer an endemic amphibian. Ecology and Evolution 4(23):4467-4475.

Salgado, M., Manning, E. J., Monti, G., Bólske, G., Soderlund, R., Ruiz, M., Paredes, E., Leiva, S., Van Kruningen, H., Kruze, J. 2011. European Hares in Chile: A Different Lagomorph Reservoir for Mycobacterium avium subsp. paratuberculosis?. Journal of Wildlife Diseases 47(3):734-738.